Research Articles

2020  |  Vol: 6(1)  |  Issue: 1 (January-February)  |  https://doi.org/10.31024/ajpp.2020.6.1.6
Encapsulation of Ketoprofen loaded lipid microspheres: Preparation, characterization and release kinetics

Vikrant Nikam1*, Sanjay Jain2, Guru Mohanta3

1Amrutvahini College of Pharmacy, Sangamner 422 608, (MS), India

2Institute of Pharmacy, Bundelkhand University, Jhansi 284128 (U.P.) India

3Department of Pharmacy, Annamalai University, Annamalai Nagar 608 002, (TN), India

*Address for Corresponding Author

Vikrant K. Nikam

Amrutvahini College of Pharmacy, Sangamner (M.S.) India 422608

 

Abstract

Objective: A melt solidification technique has been developed to obtain controlled-release lipid microspheres of Ketoprofen. The objective of the present study was to minimise the unwanted side effects of Ketoprofen drug by kinetic control of drug release by entrapping Ketoprofen into gastro resistant, biodegradable waxes such as beeswax, Ceresin Wax microspheres using congeable emulsified dispersion technique utilizing a wetting agent. Solid, discrete, reproducible free flowing microspheres were obtained. Material & Methods: The Ketoprofen loaded lipid microspheres were prepared using modified melt solidification technique. The drug loaded in microspheres was found to be stable and compatible with waxes as confirmed by DSC and FTIR methods. Result & Conclusion: The yield of the microspheres was up to 93.0%. Microspheres had smooth surfaces, with free flowing and good packing properties. It indicates that the obtained angle of repose, % Carr’s index and tapped density values were well within the limit.  More than 95.0% of the isolated spherical microspheres were in the particle size range of 310-320 µm as confirmed by scanning electron microscopy photographs. The technique and the lipid microspheres were evaluated on the basis of process and desired yield, size distribution, crushing strength, and drug release. The release of drug was controlled for more than 12h.  The release kinetics followed different transport mechanisms. The drug release performance was greatly affected by the materials used in microsphere preparations, which allows absorption in the intestinal tract.

Keywords: Ketoprofen, bees wax microsphere, ceresin wax microsphere, controlled release

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