Anand Kumar Patel, Vivek Jain, Sunil Kumar Jain, Amit Verma, Rupesh Kumar Jain*
Adina Institute of Pharmaceutical Sciences, NH, Bhopal Road, Sagar (M.P.), India – 470001
*Address for Corresponding Author
Mr. Rupesh Kumar Jain
Department of Pharmaceutics
Adina Institute of Pharmaceutical Sciences,
NH, Bhopal road, Sagar (M.P.), India – 470 001
Abstract
Colon is attracting interest as a site where poorly absorbed drug molecule may have an improved bioavailability. Additionally, the colon has a longer retention time and appears highly responsive to agents that enhance the absorption of poorly absorbed drugs. Objective: The main aim of the present research was to develop and evaluate various matrix tablet formulations of naproxen with different polymers. Material and methods: Naproxen tablets formulation was prepared for colon specific controlled release using combination of various polymer types (combination of EL100 and ES100), and (combination of EC with EL100 and ES100). Prepared tablets were characterized by physicochemical properties like weight variation, thickness, crushing strength, friability and drug content uniformity.In vitro release and kinetic studies were performed. Results and conclusion: In the present study, three formulations; viz., IEL15ES10, IEL10ES15 and IEL20EC5; were selected because they had shown good similarity with the theoretical target release profile in vitro as shown by their similarity factor f2 that was greater than 50 and dissimilarity factor f1 that was less than 15. The drug release profile from most of the selected formulations in simulated GI fluid (without enzymes) was characterized by an initial lag time period of 4-6 h with low drug release followed by controlled release phase in phosphate buffer media for about 14-16 h. Therefore, these formulations have the potential for pH and time dependent delivery to the colon.
Keywords: Matrix tablet, Colon targeting, Bioavailability, Controlled drug release, pH dependent delivery, Colon cancer
