I. Bala Tripura Sundari*, N. Hema Reddy
Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, Affiliated to Osmania University, Hyderabad, Telangana, India
*Address for Corresponding author
I. Bala Tripura Sundari
Assistant Professor
Sri Venkateshwara College of Pharmacy
Hyderabad, Affiliated to Osmania University, Hyderabad, Telangana, India
Abstra​ct
Objective: The main purpose of the work was to optimize an Ion, pH nasal In-Situ gel formulation to enhance nose-to-brain delivery of Sertraline hydrochloride, an antidepressant agent. An in situ-forming polymeric drug delivery system might be the better option to increase the drug's bioavailability. Material and method: A preliminary procedure of mixing different combinations of Xanthan gum, Konjac gum, Carbopol, and HPMC K100M, the properties of gels were tested to assess the impact of polymers. All the formulations developed were characterized for the evaluation tests. XF7 and CF6 formulations were selected as optimized formulations. These were subjected to viscosity and ex vivo permeation studies in comparison to the plain gels prepared. Results: The optimized formulations were defined by a pH value of 6.4±0.2, and a gelation time ranging from 12 to 16 seconds, demonstrating all the characteristics needed by in situ gelling formulations intended for nasal administration. Ex vivo studies also confirmed 100 % drug release from XF7 formulation in 24 hr. It retained the potential for improving drug penetration via the nasal mucosa, which is more significant. Conclusions: These findings suggest that the optimal gelling system, which uses both direct and indirect pathways at a controlled rate, maybe a practical and easy technique to enhance the delivery of Sertraline hydrochloride to the brain
Keywords: Sertraline hydrochloride, Nasal in-situ gel, pH-sensitive, Ion-sensitive
