K. Sravanthi, Tajuddin Shaik
Malla Reddy College of Pharmacy, Department of Pharmacology, Hyderabad, Telangana, 500100 India
*Address for Corresponding Author:
Mr. Tajuddin Shaik
Malla Reddy College of Pharmacy, Department of Pharmacology, Hyderabad, Telangana, 500100 India
Abstract
Background: Gentamicin, a widely used antibiotic for treating bacterial infections, is known to have nephrotoxic side effects, primarily attributed to oxidative stress and the generation of free radicals. To counteract these adverse effects, natural remedies with antioxidant properties are being actively investigated. Objectives: To evaluate nephroprotective activity of hydroalcoholic leaf Extract of Boswellia ovalifoliolata on Gentamicin-induced nephrotoxicity in albino wistar Rats. To carry out the preliminary screening, analytical studies, acute toxicity studies and nephroprotective activity of hydroalcoholic leaf extract of Boswellia ovalifoliolata. Materials and Methods: The Hydroalcoholic leaf extract of Boswellia ovalifoliolata shows presences of saponins, alkaloids, flavonoids, terpenoids, phytosterols, tannins, phenols, phyto steroids and sterols. Acute toxicity assessments indicated that the safety threshold of HALBO is as high as 2000mg/kg. Results: The biochemical factors like blood urea nitrogen, urine output, serum creatinine levels in rats were decreased in first two doses (200 and 400 mg/kg) and increased in control group. The groups that received hydroalcoholic leaf extract of Boswellia ovalifoliolata (200 mg/kg p.o. and 400 mg/kg p.o., respectively) had lower levels of glutathione reductase and malondialdehyde than the Gentamicin control group. The groups that received hydroalcoholic leaf extract of Boswellia ovalifoliolata (200 mg/kg p.o. and 400 mg/kg p.o., respectively) had higher levels of reduced glutathione and catalase than the Gentamicin control group. Conclusion: Hydroalcoholic leaf extract of Boswellia ovalifoliolata (HALBO) exhibited strong nephroprotective properties due to its rich phytochemical composition. HALBO (400 mg/kg p.o.) effectively mitigated GEN-induced renal damage through its potent free radical scavenging activity.
Keywords: Gentamicin, Boswelia ovalifoliolata, hydroalcoholic, gentamicin, nephrotoxicity, nephroprotective
