Trebissou Aïssé Florence Judith1, Okogni Okpo Jean-Noël2, Yapo Adou Francis2
1Biology Laboratory and Medical Research, National Institute of Public Health, Côte d’Ivoire. Box 47, Abidjan
2Laboratory of Natural Substances Pharmacology, UFR Bioscences, Félix Houphouët Boigny University, Abidjan, Côte d’Ivoire. Box 34, Abidjan
*Address for Corresponding Author
Trebissou Aïssé Florence Judith
National Institute of Public Health, Côte d’Ivoire, Box 47, Abidjan
Abstract
Background: Diabetes is a metabolic disease which is characterized by chronic hyperglycemia, so be it a glycemia to have eaten and drunk nothing higher than 1.6 grams/litre (7 mmole/litre) at least at two resumptions. Objective: The aim of this work is to explore the phytochemical composition and antihyperglycemic activity of mixing of Gossypium hirsutum L. and Terminalia catappa L., under form of decoction. Material and Methods : Both especies selected for this study are Gossypium hirsutum L. and Terminalia catappa L. Phytochemical characterization was carried out aid of specific colorimetric tests. Animals used for the in vivo study of antihyperglycemic activity were Wistar rats of both sexs, weighting between 100 and 225 g and two to five months old. Six groups of rats were formed. Glycemia of rats was measured aid of Accu-Chek® glucometer (Roche Diagnostics). Results: The results revealed the presence of bioactive secondary metabolites such as alkaloids, polyphenols, sterols, polyterpenes, gallic tannins and quinone compounds, suggesting interesting pharmacological properties (anti-inflammatory, antioxidants, antihyperglicemic). The fall of the glycemia is stayed significantly strong (P < 0,001) for the dose of AEGhTc at 1000 mg/kg of T90 to T180, all as for the glibenclamide. Conclusion. This study puts in front the therapeutic potentials of AEGhTc The dose of 1000 mg/kg of AEGhTc had an important antihyperglycemic activity.
Keywords: Phytochemistry, antihyperglycemia, Gossypium hirsutum L., Terminalia catappa L., diabetes, Côte d’Ivoire
