Rohan S. Chavan*, Shobharaj B. Malavi, Sandhya Giri, Rutuja Kene, Vaishnavi Patil, Samruddhi Patil
Genesis Institute of Pharmacy, Ap- Aknur Tal. Radhanagari Dist. Kolhapur, Maharashatra- 416212 India
*Address for Corresponding Author
Mr. Rohan S. Chavan
Genesis Institute of Pharmacy, Ap- Aknur Tal. Radhanagari Dist.- Kolhapur State. Maharashatra, 416212
Abstract
Background: Fever, also known as pyrexia, is a common medical sign characterized by high body temperature. Causes include infections, immune reactions, and tissue destruction. Antipyretic drugs inhibit COX-2 expression to reduce temperature but are toxic to hepatic cells and heart muscles. Natural COX-2 inhibitors have lower selectivity and less toxic. The demand for herbal medicines is increasing due to their fewer side effects. Hairy Tufted Leucas, a shrub in India, has high levels of flavonoids with antioxidant and hepatoprotective properties. Objective: This investigation aims to determine the antipyretic and hepatoprotective potential of Leucas ciliata leaves. Material and methods: The study involved drying and powdering dried leaves, grinding them into a coarse powder, and macerating them with ethanol for 7 days. The ethanol extract was then evaporated in a water bath. The extract was tested on albino rats, which were subjected to Brewer’s yeast-induced pyrexia and treated with the herbal extract orally. The study involved rats administered herbal extracts orally at doses of 200 mg/kg, distilled water and paracetamol as a drug control. The rats' rectal temperature was recorded before and after the dosing. Antipyretic activity was assessed by comparing the initial rectal temperature before and after the administration. Results and conclusion: Phytochemical screening included detecting alkaloids, carbohydrates, saponin, tannins, and flavonoids. The herbal ointment was found to be physically stable at different temperatures for four weeks. The study examines the effect of herbal extract on yeast-induced pyrexia in rat rectal temperature, comparing it to control and paracetamol. 200 mg per kg dose of a Lucas ciliata was a good antipyretic agent because it was able to decrease body temperature in albino rat. Phytochemical such as alkaloids, carbohydrates, saponin, tannins, flavonoids are present in Lucas ciliata. The Antipyretic activity observed can be attributed to the presence of flavonoids.
Keywords: Pyrexia, Leucas ciliata, Maceration, Brewer’s yeast, paracetamol, antipyretic
