Research Articles

2021  |  Vol: 7(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2021.7.3.5
A prospective observational study on assessment of adverse drug reactions in the in-patients of general medicine department at a tertiary care hospital

Dhanush Bellapu*, Padmalatha Kantamneni, Sravanthi Appikonda, Priyanka Jamalapurapu, Lavanya Eli, Lavanya Kancharla

Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh– 521108 India

*Address of Corresponding Author

Dhanush Bellapu

Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh– 521108 India

Abstract

Objective: According to World Health Organisation (WHO), “an Adverse Drug Reaction (ADR) is a response to a drug which is noxious and unintended that occurs at doses which are normally used to prophylaxis, diagnosis, therapy of disease or for the modifications of physiological function”. The main aim of the present study was to evaluate and assess the ADRs with prescribing rationale in the patients admitted in General Medicine Department at a tertiary care teaching hospital. Material and Methods: It is a Prospective Observational Study that was carried out for a period of 6 months in new Government General Hospital, Vijayawada. Results and conclusion: A total of 208 subjects were included in this study and assessed using WHO causality assessment scale, Naranjo’s Causlity assessment scale and Hartwig’s Severity assessment scale. Among the 208 subjects 54(25.96) ADRs were observed. Most of the ADRs were seen in males when compared to females between the age groups of 31-40 years and 51-60 years and affected gastrointestinal tract. Depending upon the Causality, most of the ADRs were ‘Probable’ as per WHO-UMC Causality Assessment Scale and ‘Possible’ as per Naranjo’s Causality Assessment Scale.

Keywords: ADRs, drugs, tertiary care hospital, General Medicine department, observational study, causality assessment and severity assessment

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