Manish Kumar, Dharmendra Harijan, Santram Lodhi*
Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Bhopal (M.P.) 462033
*Address for Corresponding Author
Dr. Santram Lodhi
Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Bhopal (M.P.) 462033
Abstract
Objective: Wound healing is a complex dynamic process. Wound environment changes with the changing health status of the individual. Objective of present study was to prepare and evaluate luteolin gel for diabetic wound healing effect. Material and methods: Luteolin loaded hydrogel (1%w/w) was evaluated for wound healing activity using diabetic wound model. Healing effect was compared with Povidone iodine ointment. Healing effect was observed by contraction area and assessment of various biochemical parameters e.g. hydroxyproline measurement, protein estimation, and histological study. Results were compared with standard group and found significant greater than the control group. Results and conclusion: On day 18, Luteolin loaded hydrogel (1% w/w) and reference ointment treated group of animals were showed 100% and 90% wound contraction, respectively. On day 18 no scars were observed in animal treated with Luteolin loaded hydrogel (1% w/w) and reference ointment, which was an indication for complete healing. The hydroxyproline content in animals treated with Luteolin loaded hydrogel (1%w/w) and reference ointment was found significantly (P< 0.05) greater than control group of animals. In conclusion, Luteolin having strong antioxidant and anti-inflammatory potential as already reported by various researchers. These properties of luteolin may supported in present study of Luteolin loaded hydrogel for wound healing effect in diabetic condition.
Keywords: Wound healing, Luteolin, hydrogel, Povidone iodine ointment, diabetic wound
