Nagar Nikita, Rajesh Singh Pawar*
Truba Institute of Pharmacy, Karond, Bypass Road, Bhopal, 462038, Madhya Pradesh, India
*Address for Corresponding Author
Dr. Rajesh Singh Pawar
Professor and Principal
Truba Institute of Pharmacy, Karond, Bypass Road, Bhopal, 462038, Madhya Pradesh, India
Abstract
Background: Nanotechnology is process for preparation of nanoparticle having size range of 1-100 nm. The technology enables the delivery of poorly water-soluble Raloxifene (RLX) drugs and preventing the first pass metabolism of drug and increases oral bioavailability of drugs. Objective: In this research work we prepared nano-particle of poorly water-soluble drug raloxifene, to improve the bioavailability of drug. Material and methods: Prepared formulations were characterized by FTIR, particle size and zeta potential, differential scanning calorimetry, X-Ray diffraction, surface morphology and stability study. Results and conclusion: Particle size and TEM study of formulation confirms nano sized discrete spherical globules with smooth surface area. Formulation shows extremely stability at room condition for six months that supports the fact that dried lyophilized nanocarriers may remain stable for longer period. Pharmacokinetic study shows pronounced improvement in pharmacokinetic parameters (Cmax, Tmax and [AUC] 0-24) which are responsible for enhanced absorption and bioavailability of drug from NLCs. The pharmacokinetic study of RLX loaded NLCs showed 3.75-fold significant improvement in bioavailability of poorly soluble RLX than plain drug the treatment of osteoporosis. For the commercial purpose, this dried NLCs product can be used orally either by incorporating into capsule or by making dispersion of powder in distilled water.
Keywords: Raloxifene, pharmacokinetic, nanoparticle, osteoporosis, bioavailability
