Bishnu Teli1, Suresh Kumar Dev2, Ayush Garg*2, Vijay Singh Kachawa3, Akhil Mangal4, , Vijay Kumar Bansal5, Vaibhav Rathore6, Mohini Vishwas1, Mohammad Junaid Alam Mansoori2, Yogesh Kumar Apurwa2
1Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan-313001, India
2Venkateshwar Institute of Pharmacy, Sai Tirupati University, Udaipur, Rajasthan-313015, India
3Satyam Institute of Pharmacy, Sai Tirupati University, Udaipur, Rajasthan-313015, India.
4Bhai Gurdas College of Pharmacy, Sangrur, Punjab-148002, India
5Lachoo Memorial College of Science & Technology “Pharmacy Wing” Jodhpur, Rajasthan- 342001, India
6Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Delhi Road, NH 9, Moradabad, Uttar Pradesh-244102, India
Address for Corresponding Author
Dr. Ayush Garg
Venkateshwar Institute of Pharmacy, Sai Tirupati University, Udaipur, Rajasthan-313015, India
Abstract
Background: Because of the limited efficacy of monotherapies and the rise in antibiotic resistance, topical infections caused by Staphylococcus aureus and Escherichia coli present serious issues. Known for their antibacterial and anti-inflammatory qualities, salicylic acid and aloin show promise as a combination therapy; yet, little is known about how well they work together. Objective: The purpose of this study is to assess how well salicylic acid and aloin work together to treat topical bacterial infections brought on by Escherichia coli and Staphylococcus aureus. Using a gel formulation, examine the antibacterial activity of salicylic acid and aloin against clinical isolates of Staphylococcus aureus and Escherichia coli, both separately and in combination. Methods: To ascertain the bactericidal activity of salicylic acid and aloin, preformulation studies were carried out and then in vitro experiments were carried out. The chemicals were evaluated against clinical isolates of Staphylococcus aureus and Escherichia coli both separately and in a combination gel formulation. The physicochemical characteristics of the drug-loaded gel were described, and zone of inhibition experiments were used to evaluate its effectiveness. Results: The various treatment groups were compared to each other, the combined formulation showed increased antibacterial activity. With the F3 formulation, the zone of inhibition for Staphylococcus aureus was 21 mm and for Escherichia coli it was 19 mm, suggesting a significant synergistic impact. Conclusion: In conclusion, salicylic acid and aloin show great promise as a dual therapy that works well for treating topical infections brought on by Staphylococcus aureus and Escherichia coli. This strategy might offer a viable substitute for traditional therapies, tackling issues associated with antibiotic resistance.
Keywords: Synergistic activity, salicylic acid, aloin, Staphylococcus aureus, Escherichia coli, topical bacterial infections
