Singhmura Saroja* Kumari Anamikab, De Rajiba, Pradhan Pallabia, Banik Sumana, Mandal Avijita
aDr. B. C. Roy College of Pharmacy & AHS, Durgapur (West Bengal), India
bBihar College of Pharmacy, Patna (Bihar), India
*Address for Corresponding author
Singhmura Saroj
Assistant Professor
Department of Pharmacology, Dr. B. C. Roy College of Pharmacy & AHS, Durgapur (West Bengal), India
Abstract
Objective(s): This study aims to assess the protective effects of fenugreek seed on the morphology and characteristics of spermatozoa exposed to Monosodium Glutamate (MSG) in male mice.Top of Form Materials and Methods: The experiment was performed using Albino Wistar male mice, divided into four groups, each consisting of five in number. Group C & D received 1.8 & 2.7 g kg-1 of MSG orally, group B received 2.7g kg-1 of MSG and fenugreek seed powder (1% of body weight from a 1% aqueous extract) as a supplement and group A was taken control treated with normal saline. Treatment was conducted for a period of 30 days. After the treatment period, various parameters were assessed to evaluate the morphology of spermatozoa and its characteristics. Various parameters like sperm percentage motility, sperm count, sperm morphology, Epididymal sperm viability, and testosterone level were evaluated. Results: Toxic effects were observed in MSG-treated groups, decreasing sperm motility, sperm count and increase in sperm abnormality was observed, reproductive organ-like testes weight was also found to reduced. Testosterone level also decreased. Toxic effect of MSG was found to be reduced in the group treated with fenugreek seed as a supplement. Conclusion: The MSG-induced toxicity effect has been restored by fenugreek seed powder.
Keywords: Fenugreek, Monosodium Glutamate (MSG), Sperm Morphology, Sperm motility, Sperm abnormality