Miezan Bilé Aka Patrice*, Yao N’guessan Alain Roland, Kouakou Yeboué Koffi François
Biochemistry Laboratory, UFR Biological Sciences, Peleforo Gon Coulibaly University BP 1328 Korhogo Ivory Coast
*Address for Corresponding Author
Dr. MIEZAN Bilé Aka Patrice
Biochemistry Laboratory, UFR Biological Sciences, Peleforo Gon Coulibaly University BP 1328 Korhogo Ivory Coast
Abstract
Objective: Pavetta corymbosa is a plant widely used in sub-Saharan Africa to treat conditions such as malaria, pain, and fever. There is no scientific literature on its antioxidant and antipyretic potential, hence the interest of this study, which is to evaluate the antioxidant and antipyretic potential of Pavetta corymbosa leaves, which would justify its use in traditional medicine. Materials and methods: The in vitro antioxidant effect of the aqueous and hydroethanolic extracts of Pavetta corymbosa leaves was evaluated using DPPH assay. The antipyretic potency of the aqueous and hydroethanolic extracts at doses of 200 mg/kg body weight (bw) against paracetamol (reference antipyretic) at a dose of 150 mg/kg bw was evaluated using Brewer's yeast induced pyrexia method. This method consisted of administering these extracts to rats following the induction of fever by subcutaneous injection of 20% of an aqueous suspension of brewer's yeast (S. cerevisiae) at a rate of 10 mL/kg. The temperature of the feverish rats was then measured 2 hours 30 minutes after this administration; then at regular 2-hour intervals. Results: Results of present study was showed that the hydroethanolic extract had significant antioxidant activity and febrifuge action compared to the aqueous extract (p < 0.05). However, the febrifuge effect of the hydroethanolic extract was comparable to that of paracetamol (p˃0.05). Conclusion: Hence the interest in its use in traditional medicine against certain pathologies.
Keywords: Pavetta corymbosa, febrifuge, hydroethanolic extract and antioxidant, paracetamol
