Abhishek Kurmi, Harshita Jain, Mansha Singhai, Sunil K. Jain, Amit Verma*
Adina Institute of Pharmaceutical Science, NH, Bhopal Road, Sagar (M.P.), India – 470001
*Address for Corresponding Author
Dr. Amit Verma
Department of Pharmaceutics
Adina Institute of Pharmaceutical Science, NH, Bhopal road, Sagar (M.P.), India – 470 001
E-mail: draverma1783@gmail.com
Abhishek Kurmi et al. (2023) Design and Development of Esomeprazole Loaded Polymeric Microballons as A Gastroretentive Delivery System
Asian Journal of Pharmacy and Pharmacology, 2023; Vol 9(5)
DOI: https://doi.org/10.31024/ajpp.2023.9.5.4
The article listed above was originally published with errors. These have now been corrected.
The author apologises for these errors.
Figure 1 (SEM photograph of Esomeprazole microballoons) has been removed from this manuscript. Only Figure 2 and Figure 3 are considered for reading to all authors.
Abstract
Background: Gastric retention provides advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of small intestine, for example in the treatment of peptic ulcer. Microballons have received considerable attention in pharmaceutical and biomedical application, specifically achieving sustained release and controlled release. Objectives: Thus, it is a useful method for prolonging drug release from dosage forms, reducing adverse effects and to deliver drugs in a controlled manner. Material and methods: The Esomeprazole loaded floating microballons were prepared by solvent evaporation method and effect of different variables like, drug concentration, polymer concentration, stirring time, stirring speed, and temperature was observed on their average particle size, % drug entrapment and % cumulative drug release. The optimized formulation was evaluated for parameters including average particle size, surface morphology, % cumulative drug release. Results and conclusion: The in vitro drug release study performed in all pH, confirmed that floating microballoons resulted in sustained and prolonged release of drug in the GIT fluids. It was found that more than 90 % of entrapped drug was released in 24 hours.
Keywords: Peptic Ulcer; Gastric retention; Microballons; Controlled drug delivery; Esomeprazole
