Neha Rani1, Ajay Singh Kushwah1*, Ghanshyam Das Gupta2
1Department of Pharmacology, ASBASJSMemorial College of Pharmacy, Bela-140111, Ropar, (Punjab) India
2ISF College of Pharmacy, Moga-142001 (Punjab) India
*Address for Corresponding Author
Ajay Singh Kushwah
Assistant Professor
Department of Pharmacology
ASBASJS Memorial College of Pharmacy, Bela-140111, Ropar, (Punjab) India
Tele: +91-9417459195, FAX-01881-263655
Abstract
Background: Quercetin dihydrate is a dietary flavonoid bearing antioxidant, reduce the lipid peroxidation, antitumor, and anti-inflammatory potential, present in a broad range of fruits vegetables and beverages. Objective: The present study deals with evaluating the effect of quercetin dihydrate on triton induced hyperlipidemia in rats. Materials and methods: Adult Wistar rats (either sex) divided into five groups: Normal control, Triton control, the dose of quercetin dihydrate (25, 50mg/kg; p.o.) Atorvastatin (10mg/kg; p.o.) serve as standard drug administered to triton induced hyperlipidemic rats for 28 days. Results: The results significantly demonstrated in Triton induced hyperlipidemic rats, treatment with quercetin dihydrate reduced weight gain, lipid profile, liver function, lipid peroxidation, changes in aortic lesion were also observed after treatment. This finding indicates that quercetin dihydrate contains flavonoids able to lower plasma lipid concentrations, improve oral fat tolerance, HDL level and might be beneficial in the treatment of hyperlipidemia and atherosclerosis. Conclusion: support on the results of the present study shows that quercetin dihydrate protects from triton induced hyperlipidemia due to reducing blood lipid parameters, hemodynamic parameters, and increased antioxidant status.
Keywords: Hyperlipidemia, Triton X100, Quercetin dihydrate, Oral fat tolerance test
