Ashley Ann Dilip1, Aswathi Anil1, Athira Antony1, Reshmi Rajan1, Soumya Mary Alex1*, Binu Upendran2
1Department of Pharmacy Practice, St.Joseph’s College of Pharmacy, Cherthala – 688524, Alappuzha, India
2Department of Nephrology, Lourdes Hospital, Kochi – 682012, India
*Address for Correspondence to Author:
Soumya Mary Alex
Assistant Professor
Dept. of Pharmacy Practice
St. Joseph’s College of Pharmacy, Cherthala – 688524, Alappuzha, India
Abstract
Sepsis can be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Majority of the Indian sepsis study is done in the pediatric age groups, only limited studies on adult population. The study aimed to evaluate the management of sepsis and its adherence to the Surviving Sepsis Campaign (SSC) International Guidelines 2016. This cross-sectional study (Ambispective, single-center) is being done by taking details of patients from the medical records and the Mediware system available in a tertiary care hospital, Ernakulam. A total of 320 patients, among which 117 were analysed prospectively and 203, retrospectively. The management of sepsis is done thoroughly with timely fluid therapy, antimicrobial therapy, blood component and vasopressor therapy. Adherence to SSC Guidelines-2016 (both 3-Hour and 6-Hour bundles) was found to be 57.5%. While categorizing the “Stages of Sepsis" the incidence of “sepsis” was found to be higher. Urinary Tract Infection-141 (44.06%) was the most predominent focus of infection in which E.COLI-71 (22.18%) was the frequently isolated pathogen. When correlating the CCI (Charlson Comorbidity Index) Score status (comorbidities) and outcome (alive or dead) significant association was observed. Then comparing the Quick Sequential Organ Failure Assessment (qSOFA) risk status (mortality) and outcome among the total patients it was found to be statistically significant. Drug interactions and untreated indications were the mostly occurred Drug Related Problems (DRPs) in prospective and retrospective analysis respectively.
Keywords: Sepsis, surviving sepsis campaign international guidelines, Charlson Comorbidity Index, quick sequential organ failure assessment, drug related problems
