Santosh Rathore, Mansha Singhai, Sunil K. Jain, Amit Verma*
Adina Institute of Pharmaceutical Science, NH, Bhopal Road, Sagar (M.P.), India – 470001
*Address for Corresponding Author
Dr. Amit Verma
Department of Pharmaceutics
Adina Institute of Pharmaceutical Science,
NH, Bhopal road, Sagar (M.P.), India – 470 001
Abstract
Background: Various conventional therapies for the management of Rheumatoid Arthritis (RA) are commercially available and generally used but these are associated with some various side effects. Because use of the existing or conventional therapies has its own set of limitations and risks of in terms of both safety and efficacy hence various novel approaches can be safely employed to treat this disease. Objective: To overcome the side effect and limitation of conventional drug therapy we aimed to prepare the surface modified novel drug delivery systems for efficient management of rheumatoid arthritis and to minimize the dose error problem. Material and methods: In the present work we have tried to explore the potential of the targeted nanoparticulate system for encapsulation and the delivery of selective COX-2 inhibitor etoricoxib. The BSA nanoparticles were prepared by desolvation method and the effect of various formulation and process variables on the particle size and drug entrapment efficiency was studied. Results and Conclusion: The results suggested that these variables influenced the shape, size, size distribution, and encapsulation efficiency of the nanoparticles. It could be seen that the diameter of nanoparticles decreased with the increasing content of BSA up to 0.2% concentration of BSA (w/v). From this study it may be concluded that development of folate-targeted therapeutic agents for guided intervention into arthritis may further enhance its site-specific drug delivery to activated macrophages at inflamed joints in RA and may possibly used as sustained drug delivery system in rheumatoid arthritis.
Keywords: Rheumatoid Arthritis; COX-2 inhibitor; Etoricoxib; Site-specific drug delivery; Nanoparticles; Targeted nanoparticulate system
