Research Articles

2019  |  Vol: 5(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2019.5.3.24

Neuroprotective effect of Gracilaria corticata against aluminium-induced neurotoxicity in the hippocampus and cerebral cortex of rat brain: Biochemical and histological approach

Asha Chacko^a*, Sibi P. Ittiyavirah^b

^aDepartment of Pharmaceutical Sciences, Centre of Professional and Advanced Studies, Cheruvandoor Campus, Ettumanoor- 686631, Kottayam, Kerala, India

^bDepartment of Pharmaceutical Sciences, Centre of Professional and Advanced Studies, RIMSR, Thalappady- 686009, Kottayam, Kerala, India

*Address for Corresponding author

Asha Chacko,

Department of Pharmaceutical Sciences,

Centre of Professional and Advanced Studies, Cheruvandoor Campus, Ettumanoor- 686631, Kottayam, Kerala, India

Abstract

Objective: The present study investigated the effect of ethanolic extract of Gracilaria corticata on Aluminium induced neurotoxicity. Materials and methods: Wistar rats were divided into six experimental groups.  The duration of treatment was for 60 days.  Aluminium chloride at a dose of 50mg/kg; p.o was administered to all animal group except animals in control group.  The extract at different concentration (50, 100, 200 mg/kg; p.o) and rivastigmine at 0.3mg/kg were administered along with aluminium chloride. At the end of the study, animals were sacrificed and brain processed for the evaluation of biochemical and histological analysis. Results: The ethanolic extract of Gracilaria corticata significantly ameliorated the toxic effect induced by aluminium chloride in rat hippocampus and cerebral cortex. It reduced the oxidative stress, improved acetyl cholinesterase level and morphological changes in the rat brain. Conclusion: The observed results indicated that the marine red algae, Gracilaria corticata can be used for its antioxidant and neuroprotective properties. 

Keywords: Marine algae, Al-induced, Acetyl cholinesterase, neuroprotective, oxidative stress