Rajeev Ranjan1, Mohan Lal Kori1, Santram Lodhi2*
1Vedica College of B. Pharmacy, RKDF University, Ayodhya bypaas road, Bhopal, M.P. 462033
2Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Ayodhya bypaas road, Bhopal, M.P. 462033
*Address for Corresponding Author
Dr. Santram Lodhi
Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Ayodhya bypaas road, Bhopal, M.P. 462033
Abstract
Objective: Present study was aimed to investigate potential of Corchorus aestuans for ulcerative colitis in experimental animals. Material and methods: Ethanolic extract of Corchorus aestuans was (aerial parts) use for phytochemical screening and Dextran Sulphate Sodium (DSS) Induced colitis in rats. The disease activity index and wet colon weight for different groups were observed for assessment of healing effect. Biochemical parameters MPO activity, antioxidant assessment, and MDA level in tissue were determined. Results: The disease activity index and weight of colon for colitis control group were found to be 6.25±0.68, 185.36±5.31, respectively. The disease activity index and colon weight for EECA were observed significantly decreased in dose dependent manner. DSS induced colitis significantly elevated MPO activity, whereas administration of EECA strongly inhibited MPO activity in rats with 200mg/kg as well as similar to the standard drug. Treatment with EECA exerted, to some extent, effects on reducing the colonic MDA level compared to animals that received DSS alone. The ethanolic extract of Corchorus aestuans (EECA) restored up to the normal level of antioxidant parameters, that was confirmed the potent antioxidant effect of ethanolic extract. Conclusion: The present study reveals that the improved condition of ulcerative colitis by Corchorus aestuans extract may be due to its capacity to enhance tissue antioxidant levels.
Keywords: Corchorus aestuans, ulcerative colitis, Dextran Sulphate Sodium, antioxidant
