Ajay Singh Kushwah1*, Ghanshyam Das Gupta2
1 PhD Research Scholar, IK Gujral Punjab Technical University, Jalandhar- 144603 (Punjab) India;and Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela-140111, Ropar (Punjab) India.
2 Indo-Soviet Friendship College of Pharmacy, Ferozepur Road, GhalKalan, Moga-142001,(Punjab) India.
*Address for Corresponding Author
Ajay Singh Kushwah
Assistant Professor
Department of Pharmacology
ASBASJS Memorial College of Pharmacy, Bela-140111, Ropar, (Punjab) India
Tele: +91-9417459195, FAX-01881-263655
Abstract
Background: Quercetin and Metformin, showing that the antihyperglycemic effect could be attributed to AMPK stimulation followed by gluconeogenesis process. Objectives: The aim of the present study was to investigate the effect of the individual and concomitant use of metformin and quercetin for treating of diabetic state associated with cardiovascular diseases. Material and methods: Adult healthy Wistar rats (either sex) body weight 220-250g, induction of diabetes by injection of STZ (60mg/kg). Diabetic rats were randomly divided into five different groups; (C) normal vehicle control; (STZ60) control, test groups (STZ60+M200) and (STZ60+Q50); concomitant test drug administered groups (STZ60+M200+ Q50). Daily body weights were measured and end of the study blood and hemodynamic parameters evaluated. After studies, the animals were sacrificed to estimate heart biochemical and histopathological studies were carried out. Results: Our results suggest that metformin and quercetin have significantly (P<0.05) show a preventive effect against STZ induced diabetic and cardiac dysfunction in rats, and concomitant administration of both test drugs have shown highly significant results. Conclusion: The present study indicates the concomitant use of metformin and quercetins synergize protective effect against STZ -induced diabetic as well as cardiac dysfunctions.
Keywords: Quercetin, Metformin, cardioprotective, antioxidant, Baroreflex
